Kisspeptin-10 was originally named Metastin after its ability to prevent the spread of cancer (metastasis).

Kisspeptin-10 is a peptide produced in the hypothalamus that stimulates the release of gonadotropin-releasing hormone (GnRH) which then causes luteinizing hormone (LH) and follicle-stimulating hormone (FSH) to be released from the pituitary gland.
It is used by men who are undergoing testosterone replacement therapy and often used instead of hCG to boost the body’s down testosterone and prevent testicular atrophy.

Kisspeptin enters into receptor sites in the pituitary gland, starting a reaction that causes the gland to release neurotransmitters to signal the release of LH and FH.

Some benefits may include:

• Increasing the body’s production of testosterone naturally
• Prevent testicular atrophy
• Regulate fertility
• Increases sexual arousal
• Improves mood & behavior
• Lowers the risk of heart disease
• Boosts immunity
• Promote weight loss
• Prevents wrinkles and other signs of skin aging
• Boosts brain function
• Increase ovarian function
• Regulate fertility
• May offer benefit in reproductive disorders such as Idiopathic Hypogonadotropic hypogonadism (IHH), , hypothalamic amenorrhea (HA) and Polycystic Ovarian Syndrome (PCOS)

• Kisspeptin stimulates secretion of gonadotrophin releasing hormone (GnRH)It increase LH (luteinizing hormone) and FSH (follicle-stimulating hormone) in doing so it stimulate Leydig cells resulting in increased testosterone production.
• Kisspeptin enters into receptor sites in the pituitary gland, starting a reaction that causes the gland to release neurotransmitters. Those neurotransmitters then signal the release of LH and FH. These hormones have a role to play in the production of testosterone and oestradiol. Without Kisspeptin, this entire chain reaction would be compromised.
• Kisspeptin mimics the actions of both clomiphene and hCG and therefore maintains fertility in men and deters against testicular atrophy. Has now been safely and successfully used in men and women

Kisspeptin is supplied as a dry powder for injections.
Standard dosing:

• 100 mcg subQ daily (10 units by Insulin syringe)

Others advocate for use along with TRT dosing 2-3 times a week

Ideally, the patient will take his kisspeptin-10 dosage concurrently with TRT, typically 2-3 times per week with a standard injection of . 1-. 2mL per injection at each interval.

Potential Side Effects:

• Redness at the injection site
• Acne

In healthy men, the negative feedback loop is closed when the sex hormones slow the release of (GnRH). In consequence, the relevant hormone levels remain in balance.

THE POTENTIAL THERAPEUTIC BENEFITS OF KISSPEPTIN FOR MEN’S HORMONAL FEEDBACK LOOP

This is where Kisspeptin has enormous potential to augment the progress made in testosterone replacement therapy (TRT). It does so by supporting a normal hormonal feedback loop.

TRT regimens – especially ones performed by under qualified, inexperienced providers – carry the potential to dangerously disrupt the delicate hormonal ecosystem inside the body. If done incorrectly it is possible to distort HPG axis feedback loops.

Source: OpenStax, Anatomy and Physiology of the Male Reproductive System

Men undergoing unbalanced TRT programs may experience unhealthy drops in both LH and FSH. This happens because the exogenous testosterone they receive acts — through the negative feedback loop described earlier — to slow their release.

These potential disruptions to the negative feedback loops induced for TRT demonstrate the absolute necessity of regularly monitoring all hormone levels throughout therapy. (Not just testosterone levels).

Following kisspeptin-10 administration, men reliably see significant increases in circulating levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This is due to its clinical function as an “upstream stimulator of gonadotrophin releasing hormone (GnRH) neurons.”

Hypogonadism, TRT, and Kisspeptin-10
Kisspeptin-10’s benefit of increased LH concentrations in the blood can mitigate one of the common side effects of poorly-performed TRT . “Testicular atrophy” is a condition in which the testicles shrink due to the unbalanced endocrine system.

This phenomenon is caused by a reduction in the pulse frequency of LH, which is itself caused by the inhibited production of GnRH that often occurs in therapy. In the absence of GnRH, LH production by the pituitary gland ceases, LH levels drop. In turn, testosterone levels drop (signaling hypogonadism), and any achievements made thus far in therapy are reversed.

The good news is that disruptions to the hormonal feedback loop caused by TRT are largely avoidable with a number of preventative measures. This is including but not limited the administration of kisspeptin-10 alongside TRT (potentially).