What is PT-141 and where does it come from?

The peptide Bremelanotide PT 141 is now FDA approved to treat sexual dysfunction in women. However, it has more use in men who desire firmer erections without unwanted side-effects of other erectile dysfunction medications. PT-141 wasn’t originally intended for this purpose. In fact, this synthetic peptide blend was developed from Melanotan II, a hormone that can darken skin pigmentation and induce tanning.

During initial tests, the discovery that Melanotan II caused sexual arousal and erections as side effects was accidental. These effects occurred in nine out of ten male volunteers in a study conducted at the University of Arizona by Dr. Hunter Wells. Additional research found the hormone acts on the nervous system rather than regulating arousal through the vascular system like medications such as Viagra and Cialis.

Studies have shown that the PT-141 provides libido-enhancing effects through activating the melanocortin receptors MC1R and the MC4R without tanning your skin. PT-141 is an option for the treatment of erectile dysfunction.

How is it Administered?

Your doctor will reconstitute the medicine in a container. Insulin needles will be provided, and you will be instructed on how to inject at our office. Afterward, you can keep the medication refrigerated at home and self-administer as per recommendations.

Subcutaneous injections are typically administered in areas where there are fat deposits in the body. Points of injection might include the lower abdomen or stomach area, or the thigh.

The general dosage for PT-141 Dosage: Sub Q (men and women) 2mg dose, 1 to 2 hours before sex (for first time injecting, it is recommended to inject 1mg for a test dose, then add 1mg more 30 minutes later).

Titration may be needed to achieve the desired response. You do not want to exceed 2mg in 72 hours. Everyone’s response and timing of the drug is different per person. Some see an effect within minutes, and others may take up to 2 hours after injection.